2r17 Summary

pdbe.org/2r17
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Functional architecture of the retromer cargo-recognition complex

The structure was published by Hierro, A., Rojas, A.L., Rojas, R., et al., Steven, A.C., Bonifacino, J.S., and Hurley, J.H., in 2007 in a paper entitled "Functional architecture of the retromer cargo-recognition complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vacuolar protein sorting-associated protein 29 and Vacuolar protein sorting-associated protein 35.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vacuolar protein sorting-associated protein 29 Q9UBQ0 (1-182) (VPS29_HUMAN)search Homo sapienssearch 100% 183 100%
B Vacuolar protein sorting-associated protein 29 Not available
Homo sapienssearch 100% 183 100%
C Vacuolar protein sorting-associated protein 35 Q96QK1 (483-780) (VPS35_HUMAN)search Homo sapienssearch < 90% 298 100%
D Vacuolar protein sorting-associated protein 35 Q96QK1 (483-780) (VPS35_HUMAN)search Homo sapienssearch < 90% 298 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9UBQ0 (1 - 182) Vacuolar protein sorting-associated protein 29 Homo sapiens
Q96QK1 (483 - 780) Vacuolar protein sorting-associated protein 35 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q9UBQ0) YfcE-likesearch Purple Acid Phosphatase; chain A, domain 2search PF12850: Calcineurin-like phosphoesterase superfamily domainsearch
C, D Vacuolar protein sorting-associated protein 35search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q9UBQ0) protein transportsearch intracellular protein transportsearch retrograde transport, endosome to plasma membranesearch transportsearch metabolic processsearch retrograde transport, endosome to Golgisearch protein bindingsearch metal ion bindingsearch hydrolase activitysearch protein transporter activitysearch zinc ion bindingsearch membranesearch cytoplasmsearch intracellular membrane-bounded organellesearch extracellular vesicular exosomesearch retromer complexsearch endosomesearch cytosolsearch endosome membranesearch
C, D (Q96QK1) retrograde transport, endosome to Golgisearch protein transportsearch retromer complexsearch

Chain InterPro annotation
A, B Phosphodiesterase MJ0936/Vps29search Calcineurin-like phosphoesterase domain, lpxH typesearch Metallo-dependent phosphatase-likesearch
C, D Vacuolar protein sorting-associated protein 35, Vps35search