2r17 Summary

pdbe.org/2r17
spacer

Functional architecture of the retromer cargo-recognition complex

The structure was published by Hierro, A., Rojas, A.L., Rojas, R., et al., Steven, A.C., Bonifacino, J.S., and Hurley, J.H., in 2007 in a paper entitled "Functional architecture of the retromer cargo-recognition complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vacuolar protein sorting-associated protein 29 and Vacuolar protein sorting-associated protein 35.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vacuolar protein sorting-associated protein 29 Q9UBQ0 (1-182) (VPS29_HUMAN)search Homo sapienssearch 100% 183 100%
B Vacuolar protein sorting-associated protein 29 Q9UBQ0 (1-182) (VPS29_HUMAN)search Homo sapienssearch 100% 183 100%
C Vacuolar protein sorting-associated protein 35 Q96QK1 (483-780) (VPS35_HUMAN)search Homo sapienssearch < 90% 298 100%
D Vacuolar protein sorting-associated protein 35 Q96QK1 (483-780) (VPS35_HUMAN)search Homo sapienssearch < 90% 298 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9UBQ0 (1 - 182) Vacuolar protein sorting-associated protein 29 Homo sapiens
Q96QK1 (483 - 780) Vacuolar protein sorting-associated protein 35 Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (Q9UBQ0) YfcE-likesearch PF12850: Calcineurin-like phosphoesterase superfamily domainsearch
C, D Vacuolar protein sorting-associated protein 35search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q9UBQ0) dephosphorylationsearch metabolic processsearch transportsearch protein transportsearch extracellular vesicular exosomesearch intracellular membrane-bounded organellesearch membranesearch endosome membranesearch cytoplasmsearch cytosolsearch endosomesearch phosphoserine phosphatase activitysearch metal ion bindingsearch hydrolase activitysearch
C, D (Q96QK1) retrograde transport, endosome to Golgisearch protein transportsearch retromer complexsearch

Chain InterPro annotation
A, B Phosphodiesterase MJ0936/Vps29search Calcineurin-like phosphoesterase domain, lpxH typesearch Metallo-dependent phosphatase-likesearch
C, D Vacuolar protein sorting-associated protein 35, Vps35search