2qzo Summary

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Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916

The structure was published by Bruning, J.B., Parent, A.A., Gil, G., et al., Adams, P.D., Katzenellenbogen, J.A., and Nettles, K.W., in 2010 in a paper entitled "Coupling of receptor conformation and ligand orientation determine graded activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.72 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Estrogen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 88%
B Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 91%
C Nuclear receptor coactivator 2 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 69%
D Nuclear receptor coactivator 2 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 69%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (298 - 554) Estrogen receptor Homo sapiens
Q61026 (686 - 698) Nuclear receptor coactivator 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
C, D Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P03372) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch
B (P03372) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch
C, D (Q61026) histone acetyltransferase activitysearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search