2qxs Summary

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Crystal Structure of Antagonizing Mutant 536S of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Raloxifene

The structure was published by Bruning, J.B., Parent, A.A., Gil, G., et al., Adams, P.D., Katzenellenbogen, J.A., and Nettles, K.W., in 2010 in a paper entitled "Coupling of receptor conformation and ligand orientation determine graded activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 91%
B Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (298 - 554) Estrogen receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P03372) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch