2qwp Summary

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Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #2

The structure was published by Jiang, J., Maes, E.G., Taylor, A.B., et al., Hinck, A.P., Lafer, E.M., and Sousa, R., in 2007 in a paper entitled "Structural basis of J cochaperone binding and regulation of Hsp70." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Heat shock cognate 71 kDa protein and Putative tyrosine-protein phosphatase auxilin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Heat shock cognate 71 kDa protein P19120 (1-394) (HSP7C_BOVIN)search Bos taurussearch < 90% 394 97%
B Putative tyrosine-protein phosphatase auxilin Q27974 (813-904) (AUXI_BOVIN)search Bos taurussearch < 90% 92 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19120 (1 - 394) Heat shock cognate 71 kDa protein Bos taurus
Q27974 (813 - 904) Putative tyrosine-protein phosphatase auxilin Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Actin/HSP70search Nucleotidyltransferase; domain 5search, Defensin A-likesearch, Actin; Chain A, domain 4search Hsp70 proteinsearch
B Helix Hairpinssearch DnaJ domainsearch
Chain InterPro annotation
A Heat shock protein 70 familysearch Heat shock protein 70, conserved sitesearch
B DnaJ domainsearch