2qoh Summary

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Crystal Structure of Abl kinase bound with PPY-A

The structure was published by Zhou, T., Parillon, L., Li, F., et al., Shakespeare, W., Dalgarno, D., and Zhu, X., in 2007 in a paper entitled "Crystal Structure of the T315I Mutant of Abl Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 288 97%
B Proto-oncogene tyrosine-protein kinase ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 288 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00520 (229 - 515) Proto-oncogene tyrosine-protein kinase ABL1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00520) ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch