› 2qob

X-ray diffraction
1.65Å resolution

Human EphA3 kinase domain, base structure

Released:
DOI: 10.2210/pdb2qob/pdb
PDB entry 2qob coloured by chain, front view.
PDB entry 2qob coloured by chain, side view.
PDB entry 2qob coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).
Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S
Structure 16 873-84 (2008)
PMID: 18547520

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 38.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 606-947; Coverage: 36%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BME 1 x BME
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 53.59Å b: 38.098Å c: 76.031Å
α: 90° β: 101.72° γ: 90°
R-values:
R R work R free
0.17 0.169 0.196
Expression system: Escherichia coli BL21(DE3)

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Citations

13 review citations

Structure and function of VEGF receptors.
Stuttfeld et al. (2009)
12 more

3 mentions without citation

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?
Collins et al. (2012)
2 more