2qoa Summary


Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor

The structure was published by D'Ambrosio, K., Masereel, B., Thiry, A., Scozzafava, A., Supuran, C.T., and De Simone, G., in 2007 in a paper entitled "Carbonic Anhydrase Inhibitors: Binding of Indanesulfonamides to the Human Isoform II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch metal ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch extracellular vesicular exosomesearch membranesearch axonsearch plasma membranesearch cytosolsearch myelin sheathsearch extracellular spacesearch cytoplasmsearch apical part of cellsearch microvillussearch basolateral plasma membranesearch response to organic substancesearch bicarbonate transportsearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch secretionsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch response to pHsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch regulation of anion transportsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch