2qnj Summary


Kinase and Ubiquitin-associated domains of MARK3/Par-1

The structure was published by Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., et al., Sicheri, F., Kay, L.E., and Pawson, T., in 2007 in a paper entitled "Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MAP/microtubule affinity-regulating kinase 3.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP/microtubule affinity-regulating kinase 3 P27448 (48-370) (MARK3_HUMAN)search Homo sapienssearch < 90% 328 98%
B MAP/microtubule affinity-regulating kinase 3 P27448 (48-370) (MARK3_HUMAN)search Homo sapienssearch < 90% 328 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27448 (48 - 370) MAP/microtubule affinity-regulating kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search, DNA helicase RuvA subunit, C-terminal domainsearch Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P27448) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryotesearch Protein kinase, ATP binding sitesearch