2qkr Summary


Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound

A publication describing this structure is not available. The depositing authors are Wernimont, A.K.search; Dong, A.search; Lew, J.search; Lin, Y.H.search; Hassanali, A.search; Arrowsmith, C.H.search; Edwards, A.M.search; Weigelt, J.search; Sundstrom, M.search; Bochkarev, A.search; Hui, R.search; Artz, J.D.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cdc2-like CDK2/CDC28 like protein kinase. This molecule has the UniProt identifier Q5CRJ8 (Q5CRJ8_CRYPI)search. The sample contained 313 residues which is 100% of the natural sequence. Out of 313 residues 269 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cdc2-like CDK2/CDC28 like protein kinase Q5CRJ8 (1-295) (Q5CRJ8_CRYPI)search Cryptosporidium parvum Iowa IIsearch 99% 313 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q5CRJ8 (1 - 295) Cdc2-like CDK2/CDC28 like protein kinase Cryptosporidium parvum Iowa II

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q5CRJ8) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q5CRJ8) ATP bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch