crystal structure of Chek1 in complex with inhibitor 2a
The structure was published by Brnardic, E.J., Garbaccio, R.M., Fraley, M.E., et al., Munshi, S.K., Kuo, L.C., and Kreatsoulas, C., in 2007 in a paper entitled "Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 323 residues which is < 90% of the natural sequence. Out of 323 residues 268 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: