2qgt Summary


Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to an Ether Estradiol Compound

The structure was published by Nettles, K.W., Bruning, J.B., Gil, G., et al., Kim, Y., Joachmiak, A., and Greene, G.L., in 2008 in a paper entitled "NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 92%
B Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 258 92%
C Nuclear receptor coactivator 2 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 92%
D Nuclear receptor coactivator 2 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 92%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (298 - 554) Estrogen receptor Homo sapiens
Q61026 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
C, D Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P03372) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search