2qf2 Summary


Rat cytosolic PEPCK in complex with oxaloacetic acid and GDP.

The structure was published by Sullivan, S.M. and Holyoak, T., in 2007 in a paper entitled "Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phosphoenolpyruvate carboxykinase, cytosolic [GTP].

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphoenolpyruvate carboxykinase, cytosolic [GTP] P07379 (1-622) (PCKGC_RAT)search Rattus norvegicussearch 100% 624 98%
B Phosphoenolpyruvate carboxykinase, cytosolic [GTP] P07379 (1-622) (PCKGC_RAT)search Rattus norvegicussearch 100% 624 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07379 (1 - 622) Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P07379) Phosphoenolpyruvate Carboxykinase, domain 1search, Phosphoenolpyruvate Carboxykinase, domain 2search, Phosphoenolpyruvate Carboxykinase; domain 3search PF00821: Phosphoenolpyruvate carboxykinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P07379) phosphoenolpyruvate carboxykinase activitysearch GDP bindingsearch GTP bindingsearch carboxylic acid bindingsearch carboxy-lyase activitysearch phosphoenolpyruvate carboxykinase (GTP) activitysearch purine nucleotide bindingsearch manganese ion bindingsearch metal ion bindingsearch lyase activitysearch magnesium ion bindingsearch nucleotide bindingsearch glucose metabolic processsearch glucose homeostasissearch gluconeogenesissearch internal protein amino acid acetylationsearch response to insulinsearch glycerol biosynthetic process from pyruvatesearch oxaloacetate metabolic processsearch lipid metabolic processsearch response to activitysearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Phosphoenolpyruvate carboxykinase, GTP-utilisingsearch Phosphoenolpyruvate carboxykinase, N-terminalsearch Phosphoenolpyruvate carboxykinase, C-terminalsearch Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved sitesearch