› 2q8u

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-194845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA double-strand break repair protein Mre11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 38.86 KDa
Source organism: Thermotoga maritima MSB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9X1X0 (Residues: 1-324; Coverage: 84%)
Gene names: TM_1635, mre11
Sequence domains: Calcineurin-like phosphoesterase
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 47.598Å b: 113.414Å c: 80.951Å
α: 90° β: 101.77° γ: 90°
R-values:
R R work R free
0.2 0.198 0.241
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Syed et al. (2018)
7 more

4 mentions without citation

Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.
Shin et al. (2014)
3 more