› 2q8t

X-ray diffraction
2.23Å resolution

Crystal Structure of the CC chemokine CCL14

Released:
DOI: 10.2210/pdb2q8t/pdb
PDB entry 2q8t coloured by chain, front view.
PDB entry 2q8t coloured by chain, side view.
PDB entry 2q8t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of CC chemokine CCL14.
Blain KY, Kwiatkowski W, Zhao Q, La Fleur D, Naik C, Chun TW, Tsareva T, Kanakaraj P, Laird MW, Shah R, George L, Sanyal I, Moore PA, Demeler B, Choe S
Biochemistry 46 10008-15 (2007)
PMID: 17691823

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 14 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 74 amino acids
Theoretical weight: 8.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16627 (Residues: 20-93; Coverage: 100%)
Gene names: CCL14, NCC2, SCYA14
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 94.345Å b: 78.073Å c: 59.639Å
α: 90° β: 121.65° γ: 90°
R-values:
R R work R free
0.19 0.187 0.234

Quick links

Citations

9 review citations

Alternatively activated microglia and macrophages in the central nervous system.
Franco et al. (2015)
8 more

4 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
3 more