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EBI PDBe PDBeView

PDBe Entry: 2q8f view

Structure of pyruvate dehydrogenase kinase isoform 1
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.03 Å, R-factor: 19.151%, Free R-factor: 21.248%, Spacegroup: P 41 21 2
Released 24/07/2007, deposition: 10/06/2007, last revision: 24/02/2009
Authors Kato, M.search; Li, J.search; Chuang, J.L.search; Chuang, D.T.search
Primary citation Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol.
STRUCTUREsearch vol:15, pag:992-1004 (2007) [PubMed ID 17683942 ]search
Keywords GHKL ATPase/kinase familysearch, pyruvate dehydrogenase complexsearch, mitochondrial kinasesearch, TRANSFERASEsearch
EC 2.7.11.2 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) Q15118search (A)
Solvent A
Related entries 2q8g, 2q8h, 2q8i
Polymers
Id Name Type UniProt Residues Observed
A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 Protein Q15118 (PDK1_HUMAN)search
 407 89%
Heterogens
Id Name Ligands
A POTASSIUM ION K search
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