2q7j Summary


The Wild Type Androgen Receptor Ligand Binding Domain Bound with Testosterone and a TIF2 box 3 Coactivator Peptide 740-753

The structure was published by Askew, E.B., Gampe, R.T., Stanley, T.B., Faggart, J.L., and Wilson, E.M., in 2007 in a paper entitled "Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (663-919) (ANDR_HUMAN)search Homo sapienssearch < 90% 257 96%
B Nuclear receptor coactivator 2 Q15596 (740-753) (NCOA2_HUMAN)search Homo sapienssearch < 90% 14 92%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10275 (663 - 919) Androgen receptor Homo sapiens
Q15596 (740 - 753) Nuclear receptor coactivator 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P10275) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch