Structure analysis

The Wild Type Androgen Receptor Ligand Binding Domain Bound with Testosterone and a TIF2 box 3 Coactivator Peptide 740-753

X-ray diffraction
1.9Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 11737.3 Å2
Buried surface area: 2220.66 Å2
Dissociation area: 547.09 Å2
Dissociation energy (ΔGdiss): 2.7 kcal/mol
Dissociation entropy (TΔSdiss): 7.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145245

Macromolecules

Chain: A
Length: 257 amino acids
Theoretical weight: 30.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 664-920; Coverage: 28%)
Gene names: AR, DHTR, NR3C4
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

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Chain: B
Length: 14 amino acids
Theoretical weight: 1.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15596 (Residues: 740-753; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

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