2q7i Summary

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The Wild Type Androgen Receptor Ligand Binding Domain Bound with Testosterone and an AR 20-30 Peptide

The structure was published by Askew, E.B., Gampe, R.T., Stanley, T.B., Faggart, J.L., and Wilson, E.M., in 2007 in a paper entitled "Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.87 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (663-919) (ANDR_HUMAN)search Homo sapienssearch < 90% 257 93%
B Androgen receptor P10275 (20-30) (ANDR_HUMAN)search Homo sapienssearch < 90% 11 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10275 (663 - 919) Androgen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Androgen receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P10275) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B