› 2q5s

X-ray diffraction
2.05Å resolution

Crystal Structure of PPARgamma bound to partial agonist nTZDpa

Released:
DOI: 10.2210/pdb2q5s/pdb
PDB entry 2q5s coloured by chain, front view.
PDB entry 2q5s coloured by chain, side view.
PDB entry 2q5s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Partial agonists activate PPARgamma using a helix 12 independent mechanism.
Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR
Structure 15 1258-71 (2007)
PMID: 17937915

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 274 amino acids
Theoretical weight: 31.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 233-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand NZA 2 x NZA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 89.712Å b: 62.194Å c: 117.956Å
α: 90° β: 101.05° γ: 90°
R-values:
R R work R free
0.199 0.197 0.245
Expression system: Escherichia coli

Quick links

Citations

25 review citations

MITF in melanoma: mechanisms behind its expression and activity.
Hartman et al. (2015)
24 more

23 mentions without citation

Review of the Structural and Dynamic Mechanisms of PPARĪ³ Partial Agonism.
Kroker et al. (2015)
22 more