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Crystal Structure of PPARgamma bound to partial agonist nTZDpa

X-ray diffraction
2.05Å resolution
PDB entry 2q5s coloured by chain, front view.
PDB entry 2q5s coloured by chain, side view.
PDB entry 2q5s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peroxisome proliferator-activated receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 23371.62 Å2
Buried surface area: 3932.14 Å2
Dissociation area: 1,069.2 Å2
Dissociation energy (ΔGdiss): -5.7 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153379

Macromolecules

Peroxisome proliferator-activated receptor gamma
Chains: A, B
Length: 274 amino acids
Theoretical weight: 31.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 233-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Peroxisome proliferator-activated receptor gamma in PDB entry 2q5s, assembly 1, front view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2q5s, assembly 1, side view.
Peroxisome proliferator-activated receptor gamma in PDB entry 2q5s, assembly 1, top view.
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