2q5p Summary


Crystal Structure of PPARgamma bound to partial agonist MRL24

The structure was published by Bruning, J.B., Chalmers, M.J., Prasad, S., et al., He, Y., Nettles, K.W., and Griffin, P.R., in 2007 in a paper entitled "Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome Proliferator-Activated Receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome Proliferator-Activated Receptor gamma P37231 (233-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 274 93%
B Peroxisome Proliferator-Activated Receptor gamma P37231 (233-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 274 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (233 - 505) Peroxisome Proliferator-Activated Receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P37231) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch