› 2q5g

X-ray diffraction
2.7Å resolution

Ligand binding domain of PPAR delta receptor in complex with a partial agonist

Released:
DOI: 10.2210/pdb2q5g/pdb
PDB entry 2q5g coloured by chain, front view.
PDB entry 2q5g coloured by chain, side view.
PDB entry 2q5g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design of a partial PPARdelta agonist.
Pettersson I, Ebdrup S, Havranek M, Pihera P, Korínek M, Mogensen JP, Jeppesen CB, Johansson E, Sauerberg P
Bioorg Med Chem Lett 17 4625-9 (2007)
PMID: 17560785

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 165-441; Coverage: 63%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 1FA 2 x 1FA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: C2
Unit cell:
a: 112.577Å b: 65.603Å c: 101.149Å
α: 90° β: 124.05° γ: 90°
R-values:
R R work R free
0.229 0.225 0.305
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The PPAR Ω Pocket: Renewed Opportunities for Drug Development.
Kaupang et al. (2020)
5 other articles

2 mentions without citation

Activation of PPARδ: from computer modelling to biological effects.
Kahremany et al. (2015)
1 more