EC 3.5.1.44: Protein-glutamine glutaminase
Reaction catalysed:
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3)
Systematic name:
Protein-L-glutamine amidohydrolase
Alternative Name(s):
- Destabilase
- Glutaminyl-peptide glutaminase
- Glutaminylpeptide glutaminase
- Peptidoglutaminase II
- Peptidylglutaminase II
EC 2.3.2.13: Protein-glutamine gamma-glutamyltransferase
Reaction catalysed:
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3)
Systematic name:
Protein-L-glutamine:protein-L-lysine gamma-glutamyltransferase
Alternative Name(s):
- Factor XIIIa
- Fibrin stabilizing factor
- Fibrinoligase
- Glutaminylpeptide gamma-glutamyltransferase
- Polyamine transglutaminase
- Protein-glutamine:amine gamma-glutamyltransferase
- R-glutaminyl-peptide:amine gamma-glutamyl transferase
- TGase
- Tissue transglutaminase
- Transglutaminase
GO terms
Biochemical function:
- peptide histaminyltransferase activity
- peptide noradrenalinyltransferase activity
- histone dopaminyltransferase activity
- peptide dopaminyltransferase activity
- histone serotonyltransferase activity
- peptide serotonyltransferase activity
- protein-glutamine glutaminase activity
- metal ion binding
- acyltransferase activity
- peptidase activity
- GTP binding
- protein binding
- calcium ion binding
- protein-glutamine gamma-glutamyltransferase activity
Biological process:
- regulation of apoptotic cell clearance
- cellular response to serotonin
- positive regulation of sprouting angiogenesis
- cellular response to dopamine
- cellular response to cocaine
- salivary gland cavitation
- branching involved in salivary gland morphogenesis
- bone development
- positive regulation of mitochondrial calcium ion concentration
- positive regulation of small GTPase mediated signal transduction
- positive regulation of neurogenesis
- positive regulation of cell adhesion
- positive regulation of GTPase activity
- apoptotic cell clearance
- positive regulation of apoptotic process
- regulation of apoptotic process
- negative regulation of endoplasmic reticulum calcium ion concentration
- protein deamination
- peptide cross-linking
- dopamine secretion
- gene expression
- phospholipase C-activating G protein-coupled receptor signaling pathway
- proteolysis
- chromatin remodeling
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
SCOP annotations
49310
Class:
All beta proteins
Fold:
Immunoglobulin-like beta-sandwich
Superfamily:
Transglutaminase, two C-terminal domains
Occurring in:
54044
Class:
Alpha and beta proteins (a+b)
Fold:
Cysteine proteinases
Superfamily:
Cysteine proteinases
Occurring in:
81289
Class:
All beta proteins
Fold:
Immunoglobulin-like beta-sandwich
Superfamily:
E set domains
Occurring in:
