› 2q13

X-ray diffraction
2.05Å resolution

Crystal structure of BAR-PH domain of APPL1

Released:
DOI: 10.2210/pdb2q13/pdb
PDB entry 2q13 coloured by chain, front view.
PDB entry 2q13 coloured by chain, side view.
PDB entry 2q13 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC
EMBO J 26 3484-93 (2007)
PMID: 17581628

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193847 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DCC-interacting protein 13-alpha Chain: A
Molecule details ›
Chain: A
Length: 385 amino acids
Theoretical weight: 44.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UKG1 (Residues: 5-385; Coverage: 54%)
Gene names: APPL, APPL1, DIP13A, KIAA1428
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 103.737Å b: 105.675Å c: 36.407Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Mechanisms shaping the membranes of cellular organelles.
Shibata et al. (2009)
22 more

72 mentions without citation

Perspective on genes and mutations causing retinitis pigmentosa.
Daiger et al. (2007)
71 more