› 2q0z

X-ray diffraction
2Å resolution

Crystal structure of Q9P172/Sec63 from Homo sapiens. Northeast Structural Genomics Target HR1979.

Released:
DOI: 10.2210/pdb2q0z/pdb
PDB entry 2q0z coloured by chain, front view.
PDB entry 2q0z coloured by chain, side view.
PDB entry 2q0z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Benach J, Neely H, Abashidze M, Edstrom WC, Seetharaman J, Zhao L, Fang Y, Cunningham K, Owens L, Ma L-C, Xiao R, Liu J, Baran MC, Acton TB, Rost B, Montelione GT, Tong L, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U5 small nuclear ribonucleoprotein 200 kDa helicase Chain: X
Molecule details ›
Chain: X
Length: 339 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75643 (Residues: 1808-2136; Coverage: 15%)
Gene names: ASCC3L1, BRR2, HELIC2, KIAA0788, SNRNP200
Sequence domains: Sec63 Brl domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P3121
Unit cell:
a: 94.55Å b: 94.55Å c: 74.109Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.22
Expression system: Escherichia coli

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