2pwl Summary


Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.

The structure was published by Chen, H., Ma, J., Li, W., et al., Neubert, T.A., Miller, W.T., and Mohammadi, M., in 2007 in a paper entitled "A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Fibroblast growth factor receptor 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Fibroblast growth factor receptor 2 P21802 (458-768) (FGFR2_HUMAN)search Homo sapienssearch < 90% 324 88%
B Fibroblast growth factor receptor 2 P21802 (458-768) (FGFR2_HUMAN)search Homo sapienssearch < 90% 324 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21802 (458 - 768) Fibroblast growth factor receptor 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P21802) ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch fibroblast growth factor-activated receptor activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch embryonic cranial skeleton morphogenesissearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 2search