Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
The structure was published by Nie, Z., Perretta, C., Erickson, P., et al., Averill, A., Yager, K.M., and Chu, S., in 2007 in a paper entitled "Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Casein kinase II subunit alpha. This molecule has the UniProt identifier P28523 (CSK2A_MAIZE). The sample contained 352 residues which is 100% of the natural sequence. Out of 352 residues 328 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: