2puu Summary


Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

A publication describing this structure is not available. The depositing authors are Qian, K.C.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P47811) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P47811) MAP kinase activitysearch protein bindingsearch kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch protein phosphorylationsearch positive regulation of erythrocyte differentiationsearch regulation of transcription, DNA-templatedsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of myotube differentiationsearch cartilage condensationsearch chondrocyte differentiationsearch skeletal muscle tissue developmentsearch myoblast differentiation involved in skeletal muscle regenerationsearch peptidyl-serine phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch angiogenesissearch regulation of transcription from RNA polymerase II promotersearch stress-induced premature senescencesearch positive regulation of myoblast differentiationsearch intracellular signal transductionsearch positive regulation of myoblast fusionsearch response to lipopolysaccharidesearch response to muramyl dipeptidesearch p38MAPK cascadesearch cell morphogenesissearch DNA damage checkpointsearch cellular response to DNA damage stimulussearch phosphorylationsearch apoptotic processsearch striated muscle cell differentiationsearch cellular response to lipopolysaccharidesearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of protein import into nucleussearch positive regulation of reactive oxygen species metabolic processsearch osteoclast differentiationsearch transcription, DNA-templatedsearch response to stresssearch lipopolysaccharide-mediated signaling pathwaysearch signal transduction in response to DNA damagesearch cellular response to ionizing radiationsearch glucose metabolic processsearch fatty acid oxidationsearch cytosolsearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch mitochondrionsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch