2puu Summary


Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

A publication describing this structure is not available. The depositing authors are Qian, K.C.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P47811) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47811) myoblast differentiation involved in skeletal muscle regenerationsearch DNA damage checkpointsearch cellular response to DNA damage stimulussearch positive regulation of erythrocyte differentiationsearch cellular response to vascular endothelial growth factor stimulussearch protein phosphorylationsearch chondrocyte differentiationsearch positive regulation of myotube differentiationsearch regulation of transcription, DNA-templatedsearch phosphorylationsearch cartilage condensationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch response to stresssearch vascular endothelial growth factor receptor signaling pathwaysearch cell morphogenesissearch stress-induced premature senescencesearch cellular response to lipopolysaccharidesearch negative regulation of canonical Wnt signaling pathwaysearch striated muscle cell differentiationsearch peptidyl-serine phosphorylationsearch positive regulation of myoblast fusionsearch positive regulation of protein import into nucleussearch p38MAPK cascadesearch positive regulation of transcription from RNA polymerase II promotersearch signal transduction in response to DNA damagesearch angiogenesissearch response to muramyl dipeptidesearch positive regulation of myoblast differentiationsearch intracellular signal transductionsearch regulation of transcription from RNA polymerase II promotersearch response to lipopolysaccharidesearch apoptotic processsearch osteoclast differentiationsearch transcription, DNA-templatedsearch cellular response to ionizing radiationsearch lipopolysaccharide-mediated signaling pathwaysearch glucose metabolic processsearch skeletal muscle tissue developmentsearch positive regulation of reactive oxygen species metabolic processsearch fatty acid oxidationsearch protein bindingsearch MAP kinase activitysearch protein kinase activitysearch transferase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch NFAT protein bindingsearch kinase activitysearch nucleotide bindingsearch spindle polesearch cytosolsearch cytoplasmsearch nucleussearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch