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Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

X-ray diffraction
2.5Å resolution
PDB entry 2puu coloured by chain, front view.
PDB entry 2puu coloured by chain, side view.
PDB entry 2puu coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14
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Multimeric state: monomeric
Accessible surface area: 16006.31 Å2
Buried surface area: 1348.93 Å2
Dissociation area: 674.46 Å2
Dissociation energy (ΔGdiss): -0.1 kcal/mol
Dissociation entropy (TΔSdiss): 6.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155650

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 348 amino acids
Theoretical weight: 39.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 5-352; Coverage: 97%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 14 in PDB entry 2puu, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 2puu, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 2puu, assembly 1, top view.
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