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Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding

X-ray diffraction
2.1Å resolution
PDB entry 2pu8 coloured by chain, front view.
PDB entry 2pu8 coloured by chain, side view.
PDB entry 2pu8 coloured by chain, top view.
Source organism: Bacillus subtilis
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methylthioribose kinase
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Multimeric state: homo dimer
Accessible surface area: 28554.46 Å2
Buried surface area: 3946.03 Å2
Dissociation area: 1,727.47 Å2
Dissociation energy (ΔGdiss): 16.18 kcal/mol
Dissociation entropy (TΔSdiss): 14.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-128324
Assembly 2
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Assembly Name: Methylthioribose kinase
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Multimeric state: homo tetramer
Accessible surface area: 55791.85 Å2
Buried surface area: 9202.0 Å2
Dissociation area: 4,291.6 Å2
Dissociation energy (ΔGdiss): 23.47 kcal/mol
Dissociation entropy (TΔSdiss): 43.38 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-128325

Macromolecules

Methylthioribose kinase
Chains: A, B
Length: 397 amino acids
Theoretical weight: 45.14 KDa
Source organism: Bacillus subtilis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O31663 (Residues: 1-397; Coverage: 100%)
Gene names: BSU13560, mtnK, ykrT
Pfam: Phosphotransferase enzyme family
InterPro:
CATH:
SCOP: APH phosphotransferases
Methylthioribose kinase in PDB entry 2pu8, assembly 1, front view.
Methylthioribose kinase in PDB entry 2pu8, assembly 1, side view.
Methylthioribose kinase in PDB entry 2pu8, assembly 1, top view.
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