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EBI PDBe PDBeView

PDBe Entry: 2pr9 view

Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL
Summary
Header ENDOCYTOSISsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.51 Å, R-factor: 20.4%, Free R-factor: 24.0%, Spacegroup: P 64
Released 18/03/2008, deposition: 04/05/2007, last revision: 24/02/2009
Authors Vahedi-Faridi, A.search; Haucke, V.search; Kittler, J.T.search; Kukhtina, V.search; Moss, S.J.search; Saenger, W.search; Chen, G.-J.search; Tretter, V.search; Smith, K.search; Yan, Z.search; McAinsh, K.search; Arancibia-Carcamo, L.search
Primary citation Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.
PROC.NATL.ACAD.SCI.USAsearch vol:105, pag:3616-3621 (2008) [PubMed ID 18305175 ]search
Keywords endocytosissearch, adaptorsearch, internalization peptide complexsearch, inhibitory neurotransmitter receptorsearch
Organism Rattus norvegicus(Norway rat) 10116search(A)
UniProt AP-2 complex subunit mu-1 (Mu2-adaptin) (AP-2 mu-2 chain) (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin assembly protein complex 2 medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) P84092search (A)
Gamma-aminobutyric acid receptor subunit gamma-2 precursor (GABA(A) receptor subunit gamma-2) P18508search (P)
Solvent A, P
Related entries 1bw8
Polymers
Id Name Type UniProt Residues Observed
A AP-2 complex subunit mu-1 Protein P84092 (AP2M1_RAT)search
 299 84%
P GABA(A) receptor subunit gamma-2 peptide Protein P18508 (GBRG2_RAT)search
 10 100%
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