2pov Summary


The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide

The structure was published by Alterio, V., De Simone, G., Monti, S.M., Scozzafava, A., and Supuran, C.T., in 2007 in a paper entitled "Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-258) (CAH2_HUMAN)search Homo sapienssearch 96% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 258) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch cellular response to fluid shear stresssearch kidney developmentsearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch regulation of intracellular pHsearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch secretionsearch response to pHsearch response to estrogensearch response to organic substancesearch response to steroid hormonesearch response to zinc ionsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch plasma membranesearch cytosolsearch extracellular exosomesearch extracellular spacesearch cytoplasmsearch apical part of cellsearch axonsearch basolateral plasma membranesearch myelin sheathsearch membranesearch microvillussearch carbonate dehydratase activitysearch arylesterase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch