2pob Summary


PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709

The structure was published by Trump, R.P., Cobb, J.E., Shearer, B.G., et al., Pearce, K.H., Billin, A.N., and Hoekstra, W.J., in 2007 in a paper entitled "Cocrystal structure guided array synthesis of PPARgamma inverse agonists" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator-activated receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 272 93%
B Peroxisome proliferator-activated receptor gamma P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 272 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (234 - 505) Peroxisome proliferator-activated receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P37231) steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch