2pni Summary

pdbe.org/2pni
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SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE

The structure was published by Booker, G.W., Gout, I., Downing, A.K., et al., Boyd, J., Waterfield, M.D., and Campbell, I.D., in 1993 in a paper entitled "Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1993.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN. This molecule has the UniProt identifier P23727 (P85A_BOVIN)search. The sample contained 86 residues which is < 90% of the natural sequence. Out of 86 residues 86 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN P23727 (1-84) (P85A_BOVIN)search Bos taurussearch < 90% 86 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23727 (1 - 84) PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P23727) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A SH3 domainsearch PI3 kinase, P85 regulatory subunitsearch Variant SH3 domainsearch