2pnb Summary

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STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

The structure was published by Booker, G.W., Breeze, A.L., Downing, A.K., et al., Gout, I., Waterfield, M.D., and Campbell, I.D., in 1992 in a paper entitled "Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN. This molecule has the UniProt identifier P23727 (P85A_BOVIN)search. The sample contained 104 residues which is < 90% of the natural sequence. Out of 104 residues 104 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN P23727 (328-431) (P85A_BOVIN)search Bos taurussearch < 90% 104 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23727 (328 - 431) PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P23727) phosphatidylinositol 3-kinase regulator activitysearch phosphatidylinositol 3-kinase complexsearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch