2pj4 Summary

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CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B [((R)-Benzyloxycarbonylamino-cyclohexyl-methyl)-hydroxy-phosphinoyloxy]-(3-guanidino-phenyl)-acetic acid COMPLEX

The structure was published by Adler, M., Buckman, B., Bryant, J., et al., West, C., Yuan, S., and Whitlow, M., in 2008 in a paper entitled "Structures of potent selective peptide mimetics bound to carboxypeptidase B." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carboxypeptidase B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carboxypeptidase B P09955 (111-416) (CBPB1_PIG)search Sus scrofasearch 94% 306 99%
B Carboxypeptidase B P09955 (111-416) (CBPB1_PIG)search Sus scrofasearch 94% 306 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09955 (111 - 416) Carboxypeptidase B Sus scrofa

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (P09955) Pancreatic carboxypeptidasessearch PF00246: Zinc carboxypeptidasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P09955) proteolysissearch zinc ion bindingsearch metallocarboxypeptidase activitysearch

Chain InterPro annotation
A, B Peptidase M14, carboxypeptidase Asearch