2pin Summary


Thyroid receptor beta in complex with inhibitor

The structure was published by Estebanez-Perpina, E., Arnold, L.A., Jouravel, N., et al., Webb, P., Guy, R.K., and Fletterick, R.J., in 2007 in a paper entitled "Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Thyroid hormone receptor beta-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thyroid hormone receptor beta-1 P10828 (209-461) (THB_HUMAN)search Homo sapienssearch < 90% 253 98%
B Thyroid hormone receptor beta-1 P10828 (209-461) (THB_HUMAN)search Homo sapienssearch < 90% 253 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (209 - 461) Thyroid hormone receptor beta-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P10828) nucleussearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch