2pha Summary

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Crystal structure of native, unliganded human arginase at 1.90 resolution

The structure was published by Di Costanzo, L., Pique, M.E., and Christianson, D.W., in 2007 in a paper entitled "Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Arginase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%
B Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05089 (1 - 322) Arginase-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05089) Arginase-like amidino hydrolasessearch Arginase; Chain Asearch PF00491: Arginase familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P05089) small molecule metabolic processsearch cellular response to transforming growth factor beta stimulussearch response to lipopolysaccharidesearch regulation of L-arginine importsearch maternal process involved in female pregnancysearch response to drugsearch cellular response to dexamethasone stimulussearch urea cyclesearch response to selenium ionsearch response to methylmercurysearch positive regulation of endothelial cell proliferationsearch arginine metabolic processsearch collagen biosynthetic processsearch cellular response to hydrogen peroxidesearch cellular nitrogen compound metabolic processsearch response to manganese ionsearch cellular response to glucagon stimulussearch cellular response to interleukin-4search response to cadmium ionsearch response to axon injurysearch response to aminesearch protein homotrimerizationsearch female pregnancysearch lung developmentsearch response to vitamin Asearch cellular response to lipopolysaccharidesearch mammary gland involutionsearch response to woundingsearch response to zinc ionsearch response to vitamin Esearch response to herbicidesearch response to peptide hormonesearch arginine catabolic processsearch response to steroid hormonesearch liver developmentsearch response to amino acidsearch neuronal cell bodysearch cytoplasmsearch extracellular vesicular exosomesearch neuron projectionsearch cytosolsearch extracellular spacesearch nucleussearch arginase activitysearch metal ion bindingsearch manganese ion bindingsearch hydrolase activitysearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch

Chain InterPro annotation
A, B Ureohydrolasesearch Arginasesearch Ureohydrolase, manganese-binding sitesearch Ureohydrolase domainsearch