2pha Summary

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Crystal structure of native, unliganded human arginase at 1.90 resolution

The structure was published by Di Costanzo, L., Pique, M.E., and Christianson, D.W., in 2007 in a paper entitled "Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Arginase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%
B Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05089 (1 - 322) Arginase-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05089) Arginase-like amidino hydrolasessearch Arginase; Chain Asearch PF00491: Arginase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05089) response to aminesearch regulation of L-arginine importsearch cellular response to interleukin-4search cellular response to glucagon stimulussearch response to herbicidesearch response to steroid hormonesearch cellular nitrogen compound metabolic processsearch cellular response to transforming growth factor beta stimulussearch urea cyclesearch arginine catabolic processsearch response to methylmercurysearch response to zinc ionsearch protein homotrimerizationsearch cellular response to hydrogen peroxidesearch response to selenium ionsearch positive regulation of endothelial cell proliferationsearch cellular response to dexamethasone stimulussearch response to manganese ionsearch lung developmentsearch response to axon injurysearch mammary gland involutionsearch collagen biosynthetic processsearch response to vitamin Esearch arginine metabolic processsearch small molecule metabolic processsearch response to woundingsearch response to peptide hormonesearch liver developmentsearch response to lipopolysaccharidesearch maternal process involved in female pregnancysearch response to cadmium ionsearch female pregnancysearch cellular response to lipopolysaccharidesearch response to vitamin Asearch response to amino acidsearch response to drugsearch hydrolase activitysearch manganese ion bindingsearch metal ion bindingsearch arginase activitysearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch cytoplasmsearch neuronal cell bodysearch extracellular vesicular exosomesearch extracellular spacesearch neuron projectionsearch cytosolsearch nucleussearch

Chain InterPro annotation
A, B Ureohydrolasesearch Arginasesearch Ureohydrolase, manganese-binding sitesearch Ureohydrolase domainsearch