2pha Summary

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Crystal structure of native, unliganded human arginase at 1.90 resolution

The structure was published by Di Costanzo, L., Pique, M.E., and Christianson, D.W., in 2007 in a paper entitled "Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Arginase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%
B Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05089 (1 - 322) Arginase-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05089) Arginase-like amidino hydrolasessearch Arginase; Chain Asearch PF00491: Arginase familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P05089) lung developmentsearch cellular response to dexamethasone stimulussearch response to aminesearch regulation of L-arginine importsearch arginine metabolic processsearch response to vitamin Esearch positive regulation of endothelial cell proliferationsearch response to selenium ionsearch response to lipopolysaccharidesearch response to methylmercurysearch response to woundingsearch response to vitamin Asearch response to manganese ionsearch response to amino acidsearch response to drugsearch maternal process involved in female pregnancysearch cellular nitrogen compound metabolic processsearch response to herbicidesearch cellular response to transforming growth factor beta stimulussearch response to steroid hormonesearch urea cyclesearch arginine catabolic processsearch response to zinc ionsearch response to peptide hormonesearch cellular response to glucagon stimulussearch small molecule metabolic processsearch cellular response to lipopolysaccharidesearch collagen biosynthetic processsearch protein homotrimerizationsearch cellular response to hydrogen peroxidesearch female pregnancysearch mammary gland involutionsearch liver developmentsearch response to cadmium ionsearch response to axon injurysearch cellular response to interleukin-4search cytosolsearch cytoplasmsearch nucleussearch neuronal cell bodysearch neuron projectionsearch extracellular vesicular exosomesearch extracellular spacesearch arginase activitysearch hydrolase activitysearch metal ion bindingsearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch manganese ion bindingsearch

Chain InterPro annotation
A, B Ureohydrolasesearch Arginasesearch Ureohydrolase, manganese-binding sitesearch Ureohydrolase domainsearch