2pha Summary

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Crystal structure of native, unliganded human arginase at 1.90 resolution

The structure was published by Di Costanzo, L., Pique, M.E., and Christianson, D.W., in 2007 in a paper entitled "Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Arginase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%
B Arginase-1 P05089 (1-322) (ARGI1_HUMAN)search Homo sapienssearch 98% 322 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05089 (1 - 322) Arginase-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05089) Arginase-like amidino hydrolasessearch Arginase; Chain Asearch PF00491: Arginase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05089) arginine catabolic processsearch urea cyclesearch response to peptide hormonesearch response to vitamin Esearch cellular nitrogen compound metabolic processsearch collagen biosynthetic processsearch response to cadmium ionsearch female pregnancysearch response to lipopolysaccharidesearch response to selenium ionsearch response to drugsearch liver developmentsearch arginine metabolic processsearch response to methylmercurysearch mammary gland involutionsearch response to amino acidsearch positive regulation of endothelial cell proliferationsearch response to aminesearch response to woundingsearch cellular response to interleukin-4search cellular response to glucagon stimulussearch response to zinc ionsearch lung developmentsearch small molecule metabolic processsearch response to vitamin Asearch cellular response to lipopolysaccharidesearch cellular response to hydrogen peroxidesearch cellular response to dexamethasone stimulussearch response to steroid hormonesearch cellular response to transforming growth factor beta stimulussearch response to herbicidesearch response to manganese ionsearch regulation of L-arginine importsearch maternal process involved in female pregnancysearch response to axon injurysearch protein homotrimerizationsearch metal ion bindingsearch manganese ion bindingsearch arginase activitysearch hydrolase activitysearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch neuronal cell bodysearch cytosolsearch nucleussearch neuron projectionsearch

Chain InterPro annotation
A, B Ureohydrolasesearch Arginasesearch Ureohydrolase, manganese-binding sitesearch Ureohydrolase domainsearch