› 2pbn

X-ray diffraction
1.7Å resolution

Crystal structure of the human tyrosine receptor phosphate gamma

Released:
DOI: 10.2210/pdb2pbn/pdb
PDB entry 2pbn coloured by chain, front view.
PDB entry 2pbn coloured by chain, side view.
PDB entry 2pbn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural genomics of protein phosphatases.
Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
PMID: 18058037

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase gamma Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23470 (Residues: 820-1130; Coverage: 22%)
Gene names: PTPG, PTPRG
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3221
Unit cell:
a: 107.338Å b: 107.338Å c: 67.757Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.208 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

24 review citations

Aiding and abetting roles of NOX oxidases in cellular transformation.
Block et al. (2012)
23 more

1 mention without citation

Structural genomics of protein phosphatases.
Almo et al. (2007)