› 2p8v

X-ray diffraction
1.85Å resolution

Crystal structure of human Homer3 EVH1 domain

Released:
DOI: 10.2210/pdb2p8v/pdb
PDB entry 2p8v coloured by chain, front view.
PDB entry 2p8v coloured by chain, side view.
PDB entry 2p8v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF
Science 319 476-81 (2008)
PMID: 18218901

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192588 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homer protein homolog 3 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NSC5 (Residues: 2-118; Coverage: 32%)
Gene name: HOMER3
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 49.47Å b: 49.47Å c: 80.71Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.264
Expression system: Escherichia coli

Quick links

Citations

20 review citations

T cell activation.
Smith-Garvin et al. (2009)
19 more

3 mentions without citation

Diversity of polyproline recognition by EVH1 domains.
Peterson et al. (2009)
2 more