2p8e Summary


Crystal structure of the serine/threonine phosphatase domain of human PPM1B

The structure was published by Almo, S.C., Bonanno, J.B., Sauder, J.M., et al., Zhang, Z.Y., Lawrence, D.S., and Burley, S.K., in 2007 in a paper entitled "Structural genomics of protein phosphatases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.816 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PPM1B beta isoform variant 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PPM1B beta isoform variant 6 O75688 (2-297) (PPM1B_HUMAN)search Homo sapienssearch < 90% 307 91%
B PPM1B beta isoform variant 6 O75688 (2-297) (PPM1B_HUMAN)search Homo sapienssearch < 90% 307 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75688 (2 - 297) PPM1B beta isoform variant 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphatase 2c; Domain 1search Protein phosphatase 2Csearch, Protein serine/threonine phosphatase 2C, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O75688) protein serine/threonine phosphatase activitysearch catalytic activitysearch protein dephosphorylationsearch

Chain InterPro annotation
A, B Protein phosphatase 2C, manganese/magnesium aspartate binding sitesearch Protein phosphatase 2C (PP2C)-like domainsearch Protein phosphatase 2Csearch