2p81 Summary


Engrailed homeodomain helix-turn-helix motif

The structure was published by Religa, T.L., Johnson, C.M., Vu, D.M., Brewer, S.H., Dyer, R.B., and Fersht, A.R., in 2007 in a paper entitled "The helix-turn-helix motif as an ultrafast independently folding domain: The pathway of folding of Engrailed homeodomain." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Segmentation polarity homeobox protein engrailed. This molecule has the UniProt identifier P02836 (HMEN_DROME)search. The sample contained 44 residues which is < 90% of the natural sequence. Out of 44 residues 44 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Segmentation polarity homeobox protein engrailed P02836 (469-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 44 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02836 (469 - 512) Segmentation polarity homeobox protein engrailed Drosophila melanogaster

Chain Structural classification (SCOP) Sequence family (Pfam)
A Homeodomainsearch Homeobox domainsearch, Engrailed homeobox C-terminal signature domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P02836) DNA bindingsearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Helix-turn-helix motifsearch Homeobox domainsearch Homeodomain-likesearch Homeobox, conserved sitesearch Homeodomain, metazoasearch