2p7g Summary


X-ray Structure of Estrogen Related Receptor g in complex with Bisphenol A.

The structure was published by Abad, M.C., Askari, H., O'Neill, J., et al., Springer, B., Spurlino, J., and Rentzeperis, D., in 2008 in a paper entitled "Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Estrogen-related receptor gamma. This molecule has the UniProt identifier P62508 (ERR3_HUMAN)search. The sample contained 251 residues which is < 90% of the natural sequence. Out of 251 residues 222 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen-related receptor gamma P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 251 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62508 (229 - 458) Estrogen-related receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62508) DNA bindingsearch zinc ion bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch