2p54 Summary


a crystal structure of PPAR alpha bound with SRC1 peptide and GW735

The structure was published by Sierra, M.L., Beneton, V., Boullay, A.B., et al., Xu, H.E., Xu, R.X., and Pianetti, P.M., in 2007 in a paper entitled "Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.79 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator-activated receptor alpha and Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor alpha Not available
Homo sapienssearch Not available 267 100%
B Nuclear receptor coactivator 1 Q15788 (686-696) (NCOA1_HUMAN)search Homo sapienssearch < 90% 12 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15788 (686 - 696) Nuclear receptor coactivator 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A () regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, alphasearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search