2p4y Summary


Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator

The structure was published by Einstein, M., Akiyama, T.E., Castriota, G.A., et al., Meinke, P.T., Wood, H.B., and Berger, J.P., in 2008 in a paper entitled "The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator-activated receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (231-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 277 88%
B Peroxisome proliferator-activated receptor gamma P37231 (231-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 277 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (231 - 505) Peroxisome proliferator-activated receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P37231) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch