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EBI PDBe PDBeView

PDBe Entry: 2p4t view

Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.15 Å, R-factor: 19.5%, Free R-factor: 21.5%, Spacegroup: I 41 2 2
Released 05/06/2007, deposition: 13/03/2007, last revision: 24/02/2009
Authors Divya, N.search; Grifith, E.search; Narayana, N.search
Primary citation Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
PROTEIN SCI.search vol:16, pag:1063-1068 (2007) [PubMed ID 17473013 ]search
Keywords bacterial infectionssearch, crystal structuresearch, folate metabolismsearch, NADP+search, R67 DHFRsearch, Symmetric bindingsearch, trimethoprim-resistancesearch, OXIDOREDUCTASEsearch
EC 1.5.1.3 ExPASy BRENDA search (A)
Organism Escherichia coli 562search(A)
UniProt Dihydrofolate reductase type 2 (EC 1.5.1.3) (Dihydrofolate reductase type II) P00383search (A)
Solvent A
Related entries 1vie, 1vif, 2gqv
Polymers
Id Name Type UniProt Residues Observed
A Dihydrofolate reductase type 2 Protein P00383 (DYR21_ECOLX)search
 62 93%
Heterogens
Id Name Ligands
A NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NAP search
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