2p4i Summary

pdbe.org/2p4i
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Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

The structure was published by Hodous, B.L., Geuns-Meyer, S.D., Hughes, P.E., et al., Wang, L., Whittington, D.A., and Zhao, H., in 2007 in a paper entitled "Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Angiopoietin-1 receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Angiopoietin-1 receptor Q02763 (808-1124) (TIE2_HUMAN)search Homo sapienssearch < 90% 317 81%
B Angiopoietin-1 receptor Q02763 (808-1124) (TIE2_HUMAN)search Homo sapienssearch < 90% 317 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02763 (808 - 1124) Angiopoietin-1 receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q02763) ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch