2p33 Summary

pdbe.org/2p33
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Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors

The structure was published by Alam, M., Beevers, R.E., Ceska, T., et al., Ratcliffe, A.J., Sharpe, A., and Tait, L.J., in 2007 in a paper entitled "Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of c-Jun N-terminal kinase 3. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 365 residues which is < 90% of the natural sequence. Out of 365 residues 332 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A c-Jun N-terminal kinase 3 P53779 (40-402) (MK10_HUMAN)search Homo sapienssearch 91% 365 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (40 - 402) c-Jun N-terminal kinase 3 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P53779) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P53779) protein phosphorylationsearch MAP kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch