Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
The structure was published by Alam, M., Beevers, R.E., Ceska, T., et al., Ratcliffe, A.J., Sharpe, A., and Tait, L.J., in 2007 in a paper entitled "Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of c-Jun N-terminal kinase 3. This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 365 residues which is < 90% of the natural sequence. Out of 365 residues 332 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: