› 2p1b

X-ray diffraction
2.75Å resolution

Crystal structure of human nucleophosmin-core

Released:
DOI: 10.2210/pdb2p1b/pdb
PDB entry 2p1b coloured by chain, front view.
PDB entry 2p1b coloured by chain, side view.
PDB entry 2p1b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface.
Lee HH, Kim HS, Kang JY, Lee BI, Ha JY, Yoon HJ, Lim SO, Jung G, Suh SW
Proteins 69 672-8 (2007)
PMID: 17879352

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo decamer
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleophosmin Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 122 amino acids
Theoretical weight: 13.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06748 (Residues: 9-122; Coverage: 39%)
Gene names: NPM, NPM1
Sequence domains: Nucleoplasmin/nucleophosmin domain
Structure domains: Nucleoplasmin core domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 99.262Å b: 107.841Å c: 108.694Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

The histone shuffle: histone chaperones in an energetic dance.
Das et al. (2010)
13 more

14 mentions without citation

Nucleophosmin: from structure and function to disease development.
Box et al. (2016)
13 more